Eukaryotic genomes are widely transcribed by RNA polymerase II (pol II) both within genes
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …

Polyadenylation occurs at numerous sites within 3′‐untranslated regions (3′‐UTRs) but
rarely within coding regions. How does Pol II travel through long coding regions without …

RNA polymerase IV (Pol IV) forms a complex with RNA-directed RNA polymerase 2 (RDR2)
to produce double-stranded RNA (dsRNA) precursors essential for plant gene silencing. In …

The ring-shaped cohesin complex topologically entraps two DNA molecules to establish
sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with …

Abstract The 5´–3´ exoribonuclease Rat1/Xrn2 is responsible for the termination of
eukaryotic mRNA transcription by RNAPII. Rat1 forms a complex with its partner proteins …

Abstract RNA polymerase II (RNAPII) is responsible for the synthesis of a diverse set of RNA
molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding …

The regulation of transcription by RNA polymerase II (RNAPII) underpins all cellular
processes and is perturbed in thousands of diseases. In humans, RNAPII transcribes∼ …

Boolean gates, the fundamental components of digital circuits, have been widely
investigated in synthetic biology because they permit the fabrication of biosensors and …

Objective In past work in budding yeast, we identified a nucleosomal region required for
proper interactions between the histone chaperone complex yFACT and transcribed genes …

The ring-shaped cohesin complex topologically entraps two DNAs to establish sister
chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with wide …