WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …

Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading
to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found …

The WNT signaling pathways are major regulators of organ development. Ample research
over the past few decades revealed that these pathways are critically involved in adult tissue …

Chronic lung diseases represent a major public health problem with only limited therapeutic
options. An important unmet need is to identify compounds and drugs that target key …

Radiation therapy is one of the most common treatment strategies for thorax malignancies.
One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is …

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. It is
characterized by alterations of the alveolar epithelium, myofibroblast activation, and …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …