Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …

Animals' tail posture and motion play an important role in communication, amongst others. In
domestic pigs, the debate around tail docking and tail biting has made the tail an important …

Alcohol-use-disorders are chronic relapsing illnesses, often co-morbid with anxiety. We
have previously shown using the “drinking-in-the-dark” model in mice that the stimulation of …

Abstract Serotonin (5-HT) is one of the fundamental neurotransmitters that contribute to the
information essential for an organism's normal, physiological function. Serotonin acts …

Neuropathic pain is a devastating disease that affects millions of people worldwide.
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …

Paclitaxel (PTX) is one of the most commonly used chemotherapeutic agents for various
cancer diseases. Despite its advantages, PTX also causes behavioral deficits related to …

Vortioxetine is a multimodal antidepressant drug that affects several brain neurochemicals
and has the potential to induce various pharmacological effects on the central nervous …

The 5-HT 1A receptors are an important biological target in the treatment of CNS diseases.
Recently, their importance in the context of non-CNS disease entities has also been …

Background Stress increases DNA methylation, primarily a suppressive epigenetic
mechanism catalyzed by DNA methyltransferases (DNMT), and decreases the expression of …