BACKGROUNDS: The prognosis of patients with osteosarcoma in many cases remains
poor, and life expectancy with lung metastases is around 12 months. Chemotherapy and …

A novel transcript of the GH gene has been identified in ocular tissues of chick embryos. It is,
however, unknown whether this transcript (small chicken GH, scGH) is translated. This …

Представлен обзор публикаций о роли системы гормона роста и инсулиноподобных
факторов роста в физиологии кожи, а также нарушений в этой системе при …

Recent studies suggest that acromegaly might predispose to an increased risk of benign
and malignant neoplasms, thus influencing the final outcome of the disease. The exact …

The conventional view of cytokine signaling is that receptors transmit information to the
nucleus without leaving the plasma membrane. However, accumulating data suggest that …

The lung is well established as being a postnatal target site for growth hormone (GH) action,
since pathophysiological states of GH excess and deficiency are both associated with …

A substantial body of research exists to support the production of growth hormone by cells of
the immune system. However, the function and mechanism of action of lymphocyte-derived …

A key factor governing cellular sensitivity to GH is cell surface GH receptor (GHR)
abundance, which is affected transcriptionally and posttranscriptionally. Mature cell surface …

Our understanding of the mechanisms of action of GH and its receptor, the GHR, has
advanced significantly in the last decade and has provided some important surprises. It is …

OBJECTIVES: To increase the efficacy and reduce the toxicity of cancer therapy. METHOD:
The DBM with MLT, Retinoids, vitamins E, D3, and C has a differentiating, cytostatic …