The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Resident memory T cells are non-recirculating memory T cells that persist long-term in
epithelial barrier tissues, including the gastrointestinal tract, lung, skin, and reproductive …

Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other
autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl …

The pathology of psoriasis strongly depends on IL-17A. Monoclonal antibodies blocking
either the cytokine or its receptor are among the most efficient treatments for psoriatic …

Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on the majority of
innate immune cells and to a lesser extent on parenchymal cells. Upon activation, TREM-1 …

Psoriasis is an inflammatory disease of the skin affecting 2–3% of the population,
characterized by a thickening of the epidermis and immune infiltrates throughout the dermis …

Exposure to certain drugs can elicit an induction or exacerbation of psoriasis. Although well-
conducted systematic studies on drug-related psoriasis are mostly lacking, traditionally …

Psoriasis is a complex disease triggered by genetic, immunologic, and environmental
stimuli. Many genes have been linked to psoriasis, like the psoriasis susceptibility genes …

Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih …

Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic
itch diseases are thought to be driven by both the nervous and immune systems, but the …