Antiplatelet medications remain a cornerstone of therapy for atherosclerotic cardiovascular
and cerebrovascular diseases. In primary prevention (patients with cardiovascular risk …

Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …

Background and Purpose Non‐alcoholic fatty liver disease (NAFLD) is considered to be one
of the most common chronic liver diseases across worldwide. Astaxanthin (Ax) is a …

Highlights•Enzymes are highly druggable due to the presence of discrete substrate
pockets.•Enzymology contributes throughout the value chain of lead discovery.•Quantitative …

Fibrosis is a pathophysiological hallmark of cardiorenal disease. In the heart, fibrosis leads
to contractile dysfunction and arrhythmias; in the kidney, it is the final common pathway for …

Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals
and ROS, or formed enzymically by a variety of enzymes such as those involved in the …

Diabetic patients are at increased risk of developing coronary artery disease and experience
worse clinical outcomes following acute myocardial infarction. Novel therapeutic strategies …

Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Background and Purpose There are no medications currently available to treat metabolic
inflammation. Bruton's tyrosine kinase (BTK) is highly expressed in monocytes and …

Background and Purpose Acute kidney injury (AKI) is a common and critical illness, resulting
in severe morbidity and a high mortality. There is a considerable interest in identifying novel …