ATP activation of peritubular cells drives testicular sperm transport
D Fleck, L Kenzler, N Mundt, M Strauch, N Uesaka… - Elife, 2021 - elifesciences.org
Spermatogenesis, the complex process of male germ cell proliferation, differentiation, and
maturation, is the basis of male fertility. In the seminiferous tubules of the testes …
maturation, is the basis of male fertility. In the seminiferous tubules of the testes …
Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2‐mediated mechanism
M Karpale, AJ Käräjämäki, O Kummu… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Many drugs and environmental contaminants induce
hypercholesterolemia and promote the risk of atherosclerotic cardiovascular disease. We …
hypercholesterolemia and promote the risk of atherosclerotic cardiovascular disease. We …
Emerging importance of tyrosine kinase inhibitors against cancer: quo vadis to cure?
GLOBOCAN 2020 estimated more than 19.3 million new cases, and about 10 million
patients were deceased from cancer in 2020. Clinical manifestations showed that several …
patients were deceased from cancer in 2020. Clinical manifestations showed that several …
Targeting zinc metalloenzymes in coronavirus disease 2019
Several lines of evidence support a link between the essential element zinc and the
coronavirus disease 2019 (COVID‐19). An important fact is that zinc is present in proteins of …
coronavirus disease 2019 (COVID‐19). An important fact is that zinc is present in proteins of …
Intramuscular cabotegravir and rilpivirine concentrations after switching from efavirenz‐containing regimen
S Bettonte, M Berton, F Stader… - British Journal of …, 2023 - Wiley Online Library
Aims Intramuscular cabotegravir/rilpivirine (IM CAB/RPV) are metabolized by
UGT1A1/CYP3A4. Efavirenz induces both enzymes; therefore, switching from an efavirenz …
UGT1A1/CYP3A4. Efavirenz induces both enzymes; therefore, switching from an efavirenz …
The hidden role of NLRP3 inflammasome in obesity‐related COVID‐19 exacerbations: lessons for drug repurposing
I Bertocchi, F Foglietta, D Collotta, C Eva… - British journal of …, 2020 - Wiley Online Library
COVID‐19, the illness caused by SARS‐CoV‐2, has a wide‐ranging clinical spectrum that,
in the worst‐case scenario, involves a rapid progression to severe acute respiratory …
in the worst‐case scenario, involves a rapid progression to severe acute respiratory …
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19
Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major
cause of death in intensive care units. Current treatments are only supportive, and there are …
cause of death in intensive care units. Current treatments are only supportive, and there are …
CYP11B2 inhibitor dexfadrostat phosphate suppresses the aldosterone‐to‐renin ratio, an indicator of sodium retention, in healthy volunteers
P Mulatero, M Groessl, B Vogt… - British journal of …, 2023 - Wiley Online Library
Aims High aldosterone is a key driver of hypertension and long‐term negative sequelae. We
evaluated the safety and efficacy of dexfadrostat phosphate (DP13), a novel aldosterone …
evaluated the safety and efficacy of dexfadrostat phosphate (DP13), a novel aldosterone …
Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats
Q Jiang, C Liu, S Liu, W Lu, Y Li, X Luo… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Pulmonary hypertension related to pulmonary fibrosis is classed
as WHO Group III, one of the most common groups which lacks effective treatment options …
as WHO Group III, one of the most common groups which lacks effective treatment options …
KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
YC Ryu, DH Lee, J Shim, J Park, YR Kim… - British journal of …, 2021 - Wiley Online Library
Background and Purpose The promotion of hair regeneration and growth heavily depends
on the activation of Wnt/β‐catenin signalling in the hair follicle, including dermal papilla …
on the activation of Wnt/β‐catenin signalling in the hair follicle, including dermal papilla …