The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Rationale Although reports of caffeine withdrawal in the medical literature date back more
than 170 years, the most rigorous experimental investigations of the phenomenon have …

Background Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been
established in chronic migraine. Here we assess the safety, tolerability, and efficacy of two …

The aim of this study was to assess the role of depression as a predictor of new onset of
chronic migraine (CM) among persons with episodic migraine (EM). The American Migraine …

Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is
characterized by recurrent headaches of mild to moderate intensity, bilateral location …

Migraine is a common and disabling brain disorder with a strong inherited component.
Because patients with migraine have severe and disabling attacks usually of headache with …

Studies suggest that a substantial proportion of headache sufferers presenting to headache
clinics may overuse acute medications. In some cases, overuse may be responsible for the …

Objective.—The objective of this study was to evaluate the safety and efficacy of botulinum
toxin type A (BoNT‐A; BOTOX®, Allergan, Inc.) for the prophylactic treatment of chronic daily …

Psychological stress is generally acknowledged to be a central contributor to primary
headache. Stress results from any challenge or threat, either real or perceived, to normal …

Background The role of diet in the management of the headache patient is a controversial
topic in the headache field. Objectives To review the evidence supporting the hypothesis …