Background–The presence of tumor-infiltrating lymphocytes (TILs) in the tumor
microenvironment is associated with an improved prognosis and a better response to …

Over the years, several tumor biomarkers have been suggested to foresee the prognosis
oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to …

Current immunotherapy paradigms aim to reinvigorate CD8+ T cells, but the contribution of
humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in …

Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which
the alpha and beta types have been the most extensively studied. Alpha HPV types mainly …

Simple Summary Head and neck cancer (HNC) incidence has been steadily increasing
since the 1990s. While the multimodal treatment approach for localized HNC is well …

Simple Summary This is the largest and most comprehensive assessment of the role of
human papillomavirus (HPV) in head and neck cancer (HNC) in Italy, which is a region …

Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding
molecular heterogeneity that results in severe therapy resistance and poor clinical outcome …

Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV (+) NPC), and human
papillomavirus-positive head and neck squamous cell carcinoma (HPV (+) HNSCC) are two …

Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from
the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and …

Human cancer cell lines are the most frequently used preclinical models in the study of
cancer biology and the development of therapeutics. Although anatomically diverse, human …