Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Q Sun, T Gong, M Liu, S Ren, H Yang, S Zeng, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …

Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer

Q Sun, Q Tao, T Ming, S Tang, H Zhao, M Liu, H Yang… - Phytomedicine, 2023 - Elsevier
Background Colorectal cancer (CRC) is a malignant affliction that burdens people globally.
Overactivated Hedgehog signal is highly implicated in CRC pathogenesis. Phytochemical …

[HTML][HTML] Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment

Z Zhang, Y Ji, N Hu, Q Yu, X Zhang, J Li, F Wu… - Asian Journal of …, 2022 - Elsevier
Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid
peroxidation, which may be a potential strategy for cancer therapy. Here we demonstrated …

Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine

J Ren, L Yang, S Qiu, AH Zhang, XJ Wang - Trends in Endocrinology & …, 2023 - cell.com
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various
diseases. However, complexities present in HM due to the unclear bioactive compounds …

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

X Zhu, Q Yao, P Yang, D Zhao, R Yang… - Frontiers in …, 2022 - frontiersin.org
Traditional Chinese Medicine (TCM) is extensively utilized in clinical practice due to its
therapeutic and preventative treatments for various diseases. With the development of high …

Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation

Z Zhao, J Zeng, Q Guo, K Pu, Y Yang, N Chen… - Frontiers in …, 2021 - frontiersin.org
Background Cancer stem cells (CSCs) are able to survive after cancer therapies, resulting in
tumor progression and recurrence, as is seen in colorectal cancer. Therapies targeting …

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

M Shi, Z Chen, H Gong, Z Peng, Q Sun… - Phytotherapy …, 2024 - Wiley Online Library
Current pharmaceutical research is energetically excavating the pharmacotherapeutic role
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …

Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment

K Sun, L Wu, S Wang, W Deng - Frontiers in Oncology, 2022 - frontiersin.org
Traditional Chinese medicine (TCM), including herbal medicine, acupuncture and
meditation, has a wide range of applications in China. In recent years, herbal compounding …

Licochalcone B induces DNA damage, cell cycle arrest, apoptosis, and enhances TRAIL sensitivity in hepatocellular carcinoma cells

Y Zhang, P Feng, H Wang, H Zhang, T Liang… - Chemico-Biological …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is a highly fatal disease recognized as a growing global
health crisis. Traditional Chinese herbal medicines have been used to treat patients with …