Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress

JK Knowles, I Helbig, CS Metcalf, LS Lubbers… - …, 2022 - Wiley Online Library
The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility
of precision treatments tailored to specific genetic etiologies. Despite this, current medical …

Zebrafish larvae as a behavioral model in neuropharmacology

RM Basnet, D Zizioli, S Taweedet, D Finazzi, M Memo - Biomedicines, 2019 - mdpi.com
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …

Making sense of rodent models of anhedonia

S Scheggi, MG De Montis… - International Journal of …, 2018 - academic.oup.com
A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …

Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos

M Sun, R Ding, Y Ma, Q Sun, X Ren, Z Sun, J Duan - Chemosphere, 2021 - Elsevier
Environmental exposure to nanoplastics is inevitable as the application of nanoplastics in
our daily life is more and more extensively. So, the adverse effects of nanoplastics on human …

Animal models of pain: diversity and benefits

C Abboud, A Duveau, R Bouali-Benazzouz… - Journal of neuroscience …, 2021 - Elsevier
Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders: a systematic review

RL Vaz, TF Outeiro, JJ Ferreira - Frontiers in neurology, 2018 - frontiersin.org
Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

[HTML][HTML] The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function

M Cleal, BD Fontana, DC Ranson, SD McBride… - Behavior research …, 2021 - Springer
Numerous neurodegenerative and psychiatric disorders are associated with deficits in
executive functions such as working memory and cognitive flexibility. Progress in developing …

Graphene quantum dots against human IAPP aggregation and toxicity in vivo

M Wang, Y Sun, X Cao, G Peng, I Javed, A Kakinen… - Nanoscale, 2018 - pubs.rsc.org
The development of biocompatible nanomaterials has become a new frontier in the
detection, treatment and prevention of human amyloid diseases. Here we demonstrated the …

Triadimenol promotes the production of reactive oxygen species and apoptosis with cardiotoxicity and developmental abnormalities in zebrafish

J Park, T Hong, G An, H Park, G Song, W Lim - Science of the Total …, 2023 - Elsevier
Various types of fungicides, especially triazole fungicides, are used to prevent fungal
diseases on farmlands. However, the developmental toxicity of one of the triazole fungicides …

Zebrafish (Danio rerio) as an excellent vertebrate model for the development, reproductive, cardiovascular, and neural and ocular development toxicity study of …

C Shen, Z Zuo - Environmental Science and Pollution Research, 2020 - Springer
In the past decades, the type of chemicals has gradually increased all over the world, and
many of these chemicals may have a potentially toxic effect on human health. The zebrafish …