Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …

SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …

The blood–brain barrier is a dynamic and highly organized structure that strictly regulates
the molecules allowed to cross the brain vasculature into the central nervous system. The …

Structural alterations and breakdown of the blood brain barrier (BBB) is often a primary or
secondary consequence of disease, resulting in brain oedema and the transport of …

Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is
an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic …

Background Although many therapeutic strategies for Alzheimer's disease (AD) have been
explored, these strategies are seldom used in the clinic. Therefore, AD therapeutic research …

Biomimetic nanotechnology represents a promising approach for the delivery of therapeutic
agents for the treatment of complex diseases. Recently, neuronal mitochondria have been …

Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key
pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been …

Abstract Treatment of brain tumor remains a great challenge worldwide. Development of a
stable, safe, and effective siRNA delivery system which is able to cross the impermeable …

Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …