Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound
Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration
L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …
Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface
DTT Phan, RHF Bender… - Experimental …, 2017 - journals.sagepub.com
The blood–brain barrier is a dynamic and highly organized structure that strictly regulates
the molecules allowed to cross the brain vasculature into the central nervous system. The …
the molecules allowed to cross the brain vasculature into the central nervous system. The …
A novel transwell blood brain barrier model using primary human cells
NL Stone, TJ England, SE O'Sullivan - Frontiers in cellular …, 2019 - frontiersin.org
Structural alterations and breakdown of the blood brain barrier (BBB) is often a primary or
secondary consequence of disease, resulting in brain oedema and the transport of …
secondary consequence of disease, resulting in brain oedema and the transport of …
[HTML][HTML] Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in …
Y Han, C Gao, H Wang, J Sun, M Liang, Y Feng, Q Liu… - Bioactive materials, 2021 - Elsevier
Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is
an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic …
an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic …
Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer's disease
C Gao, X Chu, W Gong, J Zheng, X Xie, Y Wang… - Journal of …, 2020 - Springer
Background Although many therapeutic strategies for Alzheimer's disease (AD) have been
explored, these strategies are seldom used in the clinic. Therefore, AD therapeutic research …
explored, these strategies are seldom used in the clinic. Therefore, AD therapeutic research …
Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice
C Gao, Y Wang, J Sun, Y Han, W Gong, Y Li, Y Feng… - Acta Biomaterialia, 2020 - Elsevier
Biomimetic nanotechnology represents a promising approach for the delivery of therapeutic
agents for the treatment of complex diseases. Recently, neuronal mitochondria have been …
agents for the treatment of complex diseases. Recently, neuronal mitochondria have been …
Neuronal mitochondria-targeted therapy for Alzheimer's disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems
Y Han, X Chu, L Cui, S Fu, C Gao, Y Li, B Sun - Drug Delivery, 2020 - Taylor & Francis
Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key
pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been …
pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been …
Brain tumor-targeted therapy by systemic delivery of siRNA with Transferrin receptor-mediated core-shell nanoparticles
L Wei, XY Guo, T Yang, MZ Yu, DW Chen… - International journal of …, 2016 - Elsevier
Abstract Treatment of brain tumor remains a great challenge worldwide. Development of a
stable, safe, and effective siRNA delivery system which is able to cross the impermeable …
stable, safe, and effective siRNA delivery system which is able to cross the impermeable …
[HTML][HTML] Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications
Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …