Pain can be both a cause and a consequence of sleep deficiency. This bidirectional
relationship between sleep and pain has important implications for clinical management of …

Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

Background Satralizumab, a humanised monoclonal antibody targeting the interleukin-6
receptor, reduced the risk of relapse in patients with neuromyelitis optica spectrum disorder …

Objective To define headache characteristics and evolution in relation to COVID-19 and its
inflammatory response. Methods This is a prospective study, comparing clinical data and …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

The vast majority of patients (> 99%) with severe acute respiratory syndrome coronavirus 2
survive immediate infection but remain at risk for persistent and/or delayed multisystem. This …

Osteoarthritis (OA) is the most common form of joint disease and a major cause of pain and
disability in the adult population. Interestingly, there are patients with symptomatic OA …

Neuroinflammation is a crucial mechanism in many neurological disorders. Injury to the
peripheral sensory nerves leads to a neuroinflammatory response in the somatosensory …