Promotion of good mental health, prevention, and early intervention before/at the onset of
mental disorders improve outcomes. However, the range and peak ages at onset for mental …

This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia | American Journal of Psychiatry Psychiatry Online Skip main navigation Close …

Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Background Schizophrenia (SCZ) is a severe psychiatric disorder that involves inflammatory
processes. The aim of this study was to explore the field of inflammation-related research in …

Introduction The global burden of disease (GBD) studies have derived detailed and
comparable epidemiological and burden of disease estimates for schizophrenia. We report …

Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally
believed that their long‐term use is harmful for patients' physical well‐being. However, there …