Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Biological processes are regulated by intermolecular interactions and chemical
modifications that do not affect protein levels, thus escaping detection in classical proteomic …

Dietary amino acids (AAs) are not only absorbed and metabolized by enterocytes but also
available to the microbiota in the gut in mammals. In addition to serving as the materials for …

The soil bacterium Pseudomonas putida KT2440 lacks a functional Embden-Meyerhof-
Parnas (EMP) pathway, and glycolysis is known to proceed almost exclusively through the …

Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging
drug. We set out to address the fundamental question of how gut microbes and nutrition, key …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Due to the ability to regulate target metabolic pathways globally and dynamically, metabolic
regulation systems composed of transcription factors have been widely used in metabolic …

Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …

A grand challenge of systems biology is to predict the kinetic responses of living systems to
perturbations starting from the underlying molecular interactions. Changes in the nutrient …