I. Introduction....................................................................... 215 II. IMPase Inhibitors...........................
....................................... 216 A. Nonlithium Cations.............................................................. 216 B …

4.2. With a-lithiated isonitriles 4.3. With a-lithiated phosphonates 4.4. With a-lithiated
carboxylates and carboxamides 4.5. With a-lithiated methyl sulfones and sulfonates 4.6 …

The therapeutic molecular sites of action for the moodstabilizing medications are unknown.
Myo-inositol monophosphatase (EC 3.1. 3.25) is a major enzyme of the inositol signaling …

In order to enhance the entry into cells of L-690,330, a bisphosphonate inhibitor of inositol
monophosphatase (IMPase; a key, enzyme in the phosphatidylinositol (Pl) cell signaling …

α-Hydroxyphosphonates are moderately potent (Ki= 6–600μM) inhibitors of the enzyme myo-
inositol monophosphatase (McLeod et al., Med. Chem. Res. 1992, 2, 96). Hydroxy-[4-(5, 6 …

Myo-inositol is a ubiquitous carbohydrate that is present in large amounts in brain tissue and
is involved in neuronal signalling and osmoregulation. This sugar is an essential component …

US5428181A - Bisphosphonate derivative - Google Patents US5428181A - Bisphosphonate
derivative - Google Patents Bisphosphonate derivative Download PDF Info Publication number …

Two magnesium ions are required for the enzymic hydrolysis of phosphate monoester
substrates of inositol monophosphatase. It has been suggested that one (buried) Mg2+ ion …

From a series of 4-hydroxyphenoxymethylene bisphosphonic acid derivatives 1-(4-
Hydroxyphenoxy)-1-(methyl) methylenebisphosphonic acid has been identified as a …

This review discusses recent progress in the synthesis of inositol phosphates and their
analogues. Most of the research published prior to 1992 has been extensively reviewed …