Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important
mechanisms responsible for the development of multidrug resistance (MDR). Selonsertib, a …

Drug resistance is a major setback for advanced therapeutics in multiple cancers. The
increasing prevalence of this resistance is a growing concern and bitter headache for the …

The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …

Background Multidrug resistance (MDR) is a complex phenomenon that frequently leads to
chemotherapy failure during cancer treatment. The overexpression of ATP-binding cassette …

Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and
ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although …