Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine
synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic …

Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the
form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer …

Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower
than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer …

Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to
proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor …

Simple Summary Cancer represents unrestricted growth with the removal of conventional
brakes that control growth under normal conditions. This requires novel mechanisms to …

Abstract Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor
microenvironment, play an indispensable role in cancer initiation, progression, metastasis …

SLC38A5/SNAT5 is a system N transporter that can mediate net inward or outward
transmembrane fluxes of neutral amino acids coupled with Na+ (symport) and H+ (antiport) …

Metabolic reprogramming in cancer necessitates increased amino acid uptake, which is
accomplished by up-regulation of specific amino acid transporters. However, not all tumors …