Partial-thickness cartilage defects, with no subchondral bone injury, do not repair
spontaneously, thus there is no clinically effective treatment for these lesions. Although the …

The cyclopentenone prostaglandin (PG) J2 is formed within the cyclopentenone ring of the
endogenous prostaglandin PG D2 by a nonenzymatic reaction. The PG J family is involved …

A pathological hallmark of Alzheimer's disease is accumulation of amyloid-β peptide (Aβ) in
senile plaques. Aβ has also been implicated in vascular degeneration in cerebral amyloid …

Osteoarthritis (OA), a chronic degenerative disease characterized mainly by damage to the
articular cartilage, is increasingly relevant to the pathological processes of senescence …

Silibinin, the flavonoid found in the milk thistle, has been shown to suppress cell growth and
exhibit anti-cancer effects. Some flavonoids were reported to inhibit angiogenesis which is …

OBJECTIVE: The prevalence of osteoarthritis (OA) is increased in aged individuals and a
direct correlation between chondrocyte apoptosis and cartilage degradation secondary to …

Selective cell death of dopaminergic neurons in the substantia nigra is the major cause of
Parkinson disease. Current evidence suggests that this cell death could be mediated by …

Articular cartilage extracellular matrix and cell function change with age and are considered
to be the most important factors in the development and progression of osteoarthritis. The …

Leukocyte elastase induces apoptosis of lung epithelial cells via alterations in mitochondrial
permeability, but the signaling pathways regulating this response remain uncertain. Here we …

Objective To examine whether cilostazol, a selective phosphodiesterase type III inhibitor,
protects rat articular chondrocytes against nitric oxide (NO)–induced apoptosis and prevents …