Abstract p53 is a crucial transcription factor with tumor suppressive properties that elicits its
function through specific target genes. It constitutes a pivotal system that integrates …

Abstract Recently, naringin (NAR; 4', 5, 7-trihydroxyflavanone-7-rhamnoglucoside) has been
shown to have cardioprotective properties. However, the specific mechanisms underlying its …

Osteoarthritis (OA), a degenerative joint disease with high prevalence among older people,
occurs from molecular or nanometer level and extends gradually to higher degrees of the …

Nitric oxide (NO) causes apoptosis and dedifferentiation of articular chondrocytes by the
modulation of extracellular signal-regulated kinase (ERK), p38 kinase, and protein kinase C …

Mitoribosome in mammalian cells is responsible for synthesis of 13 mtDNA-encoded
proteins, which are integral parts of four mitochondrial respiratory chain complexes (I, III, IV …

Baicalin is a flavonoid isolated from Scutellaria baicalensis and is known to affect multiple
biological functions, including the inhibition of aldose reductase, HIV infection, and nitric …

The tumor suppressor p53 accumulates under diverse stress conditions and affects cell
cycle progression and/or apoptosis. This has been exemplified for endogenously produced …

Nuclear factor‐κB (NF‐κB), a redox‐sensitive transcription factor, plays an important role in
the aging process. Thus, developing and identifying specific components that modulate NF …

Interleukin (IL)-1β is a major catabolic pro-inflammatory cytokine involved in cartilage
destruction-associated processes, such as loss of the differentiated chondrocyte phenotype …

Nitric oxide (NO), reported as an important inducer of apoptosis, plays a considerable role in
the pathogenetic mechanisms of articular diseases. This research aimed at investigating the …