Lead optimization of BIBR1591 to improve its telomerase inhibitory activity: design and synthesis of novel four chemical series with in silico, in vitro, and in vivo …
AA Al-Karmalawy, MHA Mousa… - Journal of Medicinal …, 2023 - ACS Publications
Herein, modifications to the previously reported BIBR1591 were conducted to obtain
bioisosteric candidates with improved activities. The% inhibition of the newly afforded …
bioisosteric candidates with improved activities. The% inhibition of the newly afforded …
Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health
and economy. Till producing successful vaccination strategies, the healthcare sectors …
and economy. Till producing successful vaccination strategies, the healthcare sectors …
Rationale design of novel substituted 1, 3, 5-triazine candidates as dual IDH1 (R132H)/IDH2 (R140Q) inhibitors with high selectivity against acute myeloid leukemia …
In this study, novel substituted 1, 3, 5-triazine candidates (4a-d, 5a-j, and 6a-d) were
designed as second-generation small molecules to act as dual IDH1 and IDH2 inhibitors …
designed as second-generation small molecules to act as dual IDH1 and IDH2 inhibitors …
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?
B Zhu, R Ouda, P de Figueiredo… - Expert Opinion on …, 2023 - Taylor & Francis
MHC class I Finding and eliminating virus-infected cells is critical for host defense. Cytotoxic
T cells have evolved into major players in this host protection mechanism. Major …
T cells have evolved into major players in this host protection mechanism. Major …
[PDF][PDF] Synthesis and Molecular Docking Analysis of New Thiazo-isoindolinedione Hybrids as Potential Inhibitors of the SARS-CoV-2 Main Protease.
S SHAAbAN, AA AL-KARMALAWY… - Oriental Journal of …, 2023 - researchgate.net
Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent
yields (up to 92%) from the reaction of thiazolidinedione and isoindoline-dione. The …
yields (up to 92%) from the reaction of thiazolidinedione and isoindoline-dione. The …
Mechanistic Insights into Targeting SARS-CoV-2 Papain-Like Protease in the Evolution and Management of COVID-19: A Comprehensive Review
NN MAGWAZA, A MUSHEBENGE, SC UGBAJA… - 2023 - preprints.org
The new coronavirus SARS-CoV-2 is the cause of the COVID-19 pandemic, which has
created an incomparable global health problem. PLpro is a key protein involved in viral …
created an incomparable global health problem. PLpro is a key protein involved in viral …