A unique and highly versatile technique, stress echocardiography (SE) is increasingly
recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for …

New insights into the pathophysiology and natural history of patients with aortic stenosis,
coupled with advances in diagnostic imaging and the dramatic evolution of transcatheter …

In the past several decades, cardiopulmonary exercise testing (CPX) has seen an
exponential increase in its evidence base. The growing volume of evidence in support of …

Aims We aimed to determine whether treatment with sildenafil improves outcomes of
patients with persistent pulmonary hypertension (PH) after correction of valvular heart …

The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator
of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large …

In patients with aortic and/or mitral valve disease the presence of pulmonary hypertension
(PH) indicates a decompensated state of the disease with left ventricular and left atrial …

Acute heart failure (AHF) represents a broad spectrum of disease states, resulting from the
interaction between an acute precipitant and a patient's underlying cardiac substrate and …

Background Trials evaluating implantable hemodynamic monitors to manage patients with
heart failure (HF) have shown reductions in HF hospitalizations but not mortality. Prior meta …

Background There are limited data on the prognostic impact of periprocedural pulmonary
hypertension (PH) after transcatheter aortic valve replacement (TAVR). Objectives The aim …

Cardiovascular diseases are the most common cause of death in the world. One of the major
causes of cardiac death is excessive apoptosis. However, multiple pathways through …