Water in nanopores and biological channels: a molecular simulation perspective

CI Lynch, S Rao, MSP Sansom - Chemical reviews, 2020 - ACS Publications
This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …

Transcendent Aspects of Proton Channels

TE DeCoursey - Annual review of physiology, 2024 - annualreviews.org
A handful of biological proton-selective ion channels exist. Some open at positive or
negative membrane potentials, others open at low or high pH, and some are light activated …

Cold atmospheric plasma cancer treatment, direct versus indirect approaches

A Malyavko, D Yan, Q Wang, AL Klein, KC Patel… - Materials …, 2020 - pubs.rsc.org
Cold atmospheric plasma (CAP), an ionized gas with near room temperature, shows a wide
application in medicine. CAP is a tunable source of complex chemical components including …

Multiple pore lining residues modulate water permeability of GlpF

K Pluhackova, V Schittny, PC Bürkner… - Protein …, 2022 - Wiley Online Library
The water permeability of aquaporins (AQPs) varies by more than an order of magnitude
even though the pore structure, geometry, as well as the channel lining residues are highly …

Functional regulation of aquaporin dynamics by lipid bilayer composition

ATP Nguyen, AT Weigle, D Shukla - Nature communications, 2024 - nature.com
With the diversity of lipid-protein interactions, any observed membrane protein dynamics or
functions directly depend on the lipid bilayer selection. However, the implications of lipid …

Osmotic water permeation through a carbon nanotube

C Fang, D Huang, J Su - The Journal of Physical Chemistry Letters, 2020 - ACS Publications
Osmosis are essential for not only the application of nanofluidic devices but also the
understanding of working principles of biological transmembrane proteins. Despite …

Beyond the channels: adhesion functions of aquaporin 0 and connexin 50 in lens development

Z Li, Y Quan, S Gu, JX Jiang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Lens, an avascular tissue involved in light transmission, generates an internal
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …

In vivo macromolecular crowding is differentially modulated by aquaporin 0 in zebrafish lens: Insights from a nanoenvironment sensor and spectral imaging

I Vorontsova, A Vallmitjana, B Torrado, TF Schilling… - Science …, 2022 - science.org
Macromolecular crowding is crucial for cellular homeostasis. In vivo studies of
macromolecular crowding and water dynamics are needed to understand their roles in …

Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma

M Li, M He, F Xu, Y Guan, J Tian, Z Wan, H Zhou… - PLoS …, 2022 - journals.plos.org
Aquaporins (AQPs) are a kind of transmembrane proteins that exist in various organs of the
human body. AQPs play an important role in regulating water transport, lipid metabolism and …

Association of alpha-crystallin with fiber cell plasma membrane of the eye lens accompanied by light scattering and cataract formation

R Timsina, L Mainali - Membranes, 2021 - mdpi.com
α-crystallin is a major protein found in the mammalian eye lens that works as a molecular
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …