SARS-CoV-2/COVID-19: evolving reality, global response, knowledge gaps, and opportunities
Approximately 3 billion people around the world have gone into some form of social
separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS …
separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS …
Towards systems immunology of critical illness at scale: from single cell 'omics to digital twins
Y Vodovotz - Trends in immunology, 2023 - cell.com
Single-cell 'omics methodology has yielded unprecedented insights based largely on data-
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …
Efficient Bayesian inference for stochastic agent-based models
The modelling of many real-world problems relies on computationally heavy simulations of
randomly interacting individuals or agents. However, the values of the parameters that …
randomly interacting individuals or agents. However, the values of the parameters that …
Modelling structure and dynamics of microbial community in aquatic ecosystems: The importance of hydrodynamic processes
C Hui, Y Li, W Zhang, C Zhang, L Niu, L Wang… - Journal of …, 2022 - Elsevier
Microbial communities are essential roles in aquatic ecosystems, which participate in a
number of biogeochemical processes, and are vital for the protection and ecological …
number of biogeochemical processes, and are vital for the protection and ecological …
Interleukin‐17 as a spatiotemporal bridge from acute to chronic inflammation: Novel insights from computational modeling
A systematic review of several acute inflammatory diseases ranging from sepsis and
trauma/hemorrhagic shock to the relevant pathology of the decade, COVID‐19, points to the …
trauma/hemorrhagic shock to the relevant pathology of the decade, COVID‐19, points to the …
[HTML][HTML] Digitize your Biology! Modeling multicellular systems through interpretable cell behavior
JAI Johnson, GL Stein-O'Brien, M Booth, R Heiland… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cells are fundamental units of life, constantly interacting and evolving as dynamical systems.
While recent spatial multi-omics can quantitate individual cells' characteristics and …
While recent spatial multi-omics can quantitate individual cells' characteristics and …
A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons
CT Michael, SA Almohri, JJ Linderman… - Frontiers in Systems …, 2024 - frontiersin.org
Computational models of disease progression have been constructed for a myriad of
pathologies. Typically, the conceptual implementation for pathology-related in silico …
pathologies. Typically, the conceptual implementation for pathology-related in silico …
Systems biology approaches to investigate the role of granulomas in TB-HIV coinfection
A Hoerter, E Arnett, LS Schlesinger… - Frontiers in …, 2022 - frontiersin.org
The risk of active tuberculosis disease is 15-21 times higher in those coinfected with human
immunodeficiency virus-1 (HIV) compared to tuberculosis alone, and tuberculosis is the …
immunodeficiency virus-1 (HIV) compared to tuberculosis alone, and tuberculosis is the …
Individual-Based Modeling of Spatial Dynamics of Chemotactic Microbial Populations
C Ni, T Lu - ACS synthetic biology, 2022 - ACS Publications
One important direction of synthetic biology is to establish desired spatial structures from
microbial populations. Underlying this structural development process are different driving …
microbial populations. Underlying this structural development process are different driving …
Selenocompounds and Sepsis—Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis
X Forceville, P Van Antwerpen, D Annane… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: Endothelial barrier damage, which is in part caused by excess production of
reactive oxygen, halogen and nitrogen species (ROHNS), especially peroxynitrite (ONOO−) …
reactive oxygen, halogen and nitrogen species (ROHNS), especially peroxynitrite (ONOO−) …