17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key
role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid …

Endometriosis is a complex estrogen-dependent disease that is defined as the presence of
endometrial glands and stroma outside the uterine cavity. The etiology of endometriosis is …

Introduction Endometriosis is an estrogen-dependent disease on the background of
progesterone resistance. Increased estrogen production, low estrogen metabolization, and …

Disturbed action of sex steroid hormones, ie androgens and estrogens, is involved in the
pathogenesis of various severe diseases in humans. Interestingly, recent studies have …

Importance of the field: 17β-Hydroxysteroid dehydrogenases (17β-HSDs) mainly catalyze
the reduction of C17-ketosteroids to their corresponding hydroxylated forms as well as the …

At the late 1940s, 17β-HSD1 was discovered as the first member of the 17β-HSD family with
its gene cloned. The three-dimensional structure of human 17β-HSD1 is the first example of …

Introduction Endometriosis is an estrogen-dependent disease that gives rise to pelvic pain
and infertility. Although estroprogestins and progestins currently stand as the first-line …

Context: Testicular adrenal rest tumors (TART) are one of the major long term complications
in patients with congenital adrenal hyperplasia. Although several adrenal-like properties …

Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl
alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and …

Context: The local interconversions between estrone (low activity) and 17β-estradiol (potent
compound) by 17β-hydroxysteroid dehydrogenases (17β-HSDs) can lead to high 17β …