The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …

Введение В короткой преамбуле хочется предпослать этому доку менту несколько
определяющих позиций: Принятие в 2003 и 2006 годах съездами ВНок Нацио 1 …

Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …

Although the human gut microbiome plays a prominent role in xenobiotic transformation,
most of the genes and enzymes responsible for this metabolism are unknown. Recently, we …

Digitalis is the oldest compound in cardiovascular medicine that continues to be used in
contemporary clinical practice. 1 Evidence supporting the beneficial effects of digoxin on …

CRISPR/Cas systems are powerful tools for sensitive nucleic acid molecular diagnosis due
to their specific nucleic acid recognition and high trans-cleavage activity and have also …

Cardiac glycosides (CGs) are natural compounds sharing the ability to operate as potent
inhibitors of the plasma membrane Na+/K+-ATPase, hence promoting—via an indirect …

OBJECTIVE: Ion transporters play pivotal roles in cancer cell migration in general and in
glioblastomas (GBMs) in particular. However, the specific role of Na+/K+-ATPase (the …

We have observed recently that experimental renal failure in the rat is accompanied by
increases in circulating concentrations of the cardiotonic steroid, marinobufagenin (MBG) …

Digoxin is the oldest cardiac medication used in contemporary medicine. With a complex
pharmacokinetic profile and narrow therapeutic index, its use in managing patients with …