The development of a universal sensing mechanism for the rapid and quantitative detection
of small molecules directly in whole blood would drastically impact global health by enabling …

The sodium pump, Na+/K+-ATPase, could be an important target for the development of
anticancer drugs as it serves as a versatile signal transducer, plays a key role in cell …

Objective: Because ouabain activates several pathways that are critical to cardioprotective
mechanisms such as ischemic preconditioning, we tested if this digitalis compound could …

Objective: To investigate potential interactions between rivaroxaban, an oral direct Factor Xa
inhibitor approved for the management of thromboembolic disorders, and digoxin or …

To date, up to 65% of drugs used in neonates and infants are off-label or unlicensed, as they
were implemented in clinical care without the usual regulatory phases of pharmacological …

Many common cardiovascular drugs exhibit different therapeutic outcomes and adverse
effects between women and men. The different responses may reflect gender-specific …

Covering: early studies through to March 2016 Cardenolides and bufadienolides constitute
an attractive class of biologically active steroid derivatives which have been used for the …

Plants of the Digitalis genus contain a cocktail of cardenolides commonly prescribed to treat
heart failure. Cardenolides in Digitalis extracts have been conventionally quantified by high …

Recent research has shown that the Na+/K+-ATPase a1 subunit is a novel anti-cancer
target, which plays pivotal roles in malignant cell ion transport, metabolism, migration and …

Digoxin is a high‐alert medication because of its narrow therapeutic range and high drug‐to‐
drug interactions (DDIs). Approximately 50% of digoxin toxicity cases are preventable, which …