Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides
Aims Recent studies suggest that proarrhythmic effects of cardiac glycosides (CGs) on
cardiomyocyte Ca2+ handling involve generation of reactive oxygen species (ROS) …
cardiomyocyte Ca2+ handling involve generation of reactive oxygen species (ROS) …
A perspective on re‐evaluating digoxin's role in the current management of patients with chronic systolic heart failure: targeting serum concentration to reduce …
KF Adams Jr, JK Ghali… - European journal of …, 2014 - Wiley Online Library
Digoxin improves exercise tolerance and reduces hospitalizations in patients with systolic
heart failure, but its use has declined progressively for the past two decades. The Digitalis …
heart failure, but its use has declined progressively for the past two decades. The Digitalis …
Low-dose cardiotonic steroids increase sodium–potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia
M Oselkin, D Tian, PJ Bergold - Neuroscience letters, 2010 - Elsevier
The sodium–potassium ATPase (Na/K ATPase) is a major ionic transporter in the brain and
is responsible for the maintenance of the Na+ and K+ gradients across the cell membrane …
is responsible for the maintenance of the Na+ and K+ gradients across the cell membrane …
Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination
J Mendell, RJ Noveck, M Shi - Journal of cardiovascular …, 2022 - journals.lww.com
The oral anticoagulant edoxaban, a factor Xa inhibitor, will likely be coadministered with
digoxin in some patients with atrial fibrillation. Both drugs are substrates for P–glycoprotein …
digoxin in some patients with atrial fibrillation. Both drugs are substrates for P–glycoprotein …
In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
Background Dilated cardiomyopathy (DCM) is one of the most common causes of heart
failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked …
failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked …
Digoxin therapy and associated clinical outcomes in the MADIT-CRT trial
Background Digoxin's pharmacological, hemodynamic, and electrophysiological properties
are well understood. However, in modern heart failure (HF) treatment, its effect has yet to be …
are well understood. However, in modern heart failure (HF) treatment, its effect has yet to be …
Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract
IA El‐Shimy, MMA Mohamed… - Pharmacology …, 2021 - Wiley Online Library
As the death toll of Coronavirus disease 19 (COVID‐19) continues to rise worldwide, it is
imperative to explore novel molecular mechanisms for targeting SARS‐CoV‐2. Rather than …
imperative to explore novel molecular mechanisms for targeting SARS‐CoV‐2. Rather than …
The role of cardiotonic steroids in the pathogenesis of cardiomyopathy in chronic kidney disease
D Pavlovic - Nephron Clinical Practice, 2014 - karger.com
Cardiotonic steroids (CTS) are a new class of hormones that circulate in the blood and are
divided into two distinct groups, cardenolides, such as ouabain and digoxin, and …
divided into two distinct groups, cardenolides, such as ouabain and digoxin, and …
The crystal structure of progesterone 5β-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductases
Progesterone 5β-reductase (5β-POR) catalyzes the stereospecific reduction of progesterone
to 5β-pregnane-3, 20-dione and is a key enzyme in the biosynthetic pathway of …
to 5β-pregnane-3, 20-dione and is a key enzyme in the biosynthetic pathway of …
Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors
HT Ho, SCW Stevens, R Terentyeva… - The Journal of …, 2011 - Wiley Online Library
Non‐Technical Summary Cardiac glycosides (CGs) have been routinely used in the
treatment of congestive heart failure (HF). Unfortunately, the therapeutic use of CGs in …
treatment of congestive heart failure (HF). Unfortunately, the therapeutic use of CGs in …