UNBS1450: A new hemi‐synthetic cardenolide with promising anti‐cancer activity

T Mijatovic, F Lefranc… - Drug Development …, 2007 - Wiley Online Library
Several reports suggest the sodium pump as an interesting oncology target, given that its
subunit expression is markedly altered in cancer. By binding to the sodium pump …

Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs

M Jensen, S Schmidt, NU Fedosova… - Bioorganic & medicinal …, 2011 - Elsevier
The cardiac glycoside digitoxin, consisting of a steroid core linked to a labile trisaccharide,
has been used for centuries for the treatment of congestive heart failure. The well known …

Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W. 1.4)

RM de Pádua, N Meitinger, JD de Souza Filho… - Steroids, 2012 - Elsevier
Cell cultures of Digitalis species are known to accept exogenous substrates for
biotransformation reactions. We here report the biotransformation of 21-O-acetyl …

Impact of digoxin utilization on clinical outcomes following left ventricular assist device implantation

MA Abbasi, DA Stoller, E Lyden… - … Journal of Artificial …, 2022 - journals.sagepub.com
Introduction: We aimed to assess the impact of digoxin use following left ventricular assist
device (LVAD) implantation on clinical outcomes. Methods: Patients implanted with …

The safety of digoxin as a pharmacological treatment of atrial fibrillation

J Tamargo, E Delpón, R Caballero - Expert Opinion on Drug Safety, 2006 - Taylor & Francis
Digoxin has traditionally been the drug of choice for ventricular rate control in patients with
chronic atrial fibrillation (AF), with or without heart failure (HF) with systolic dysfunction. In …

Using untargeted LC-MS metabolomics to identify the association of biomarkers in cattle feces with marbling standard longissimus lumborum

D Chen, M Su, H Zhu, G Zhong, X Wang, W Ma… - Animals, 2022 - mdpi.com
Simple Summary To improve the grade of beef marbling has great economic value in the
cattle industry since marbling has the traits of high quality and comprehensive nutrition. This …

[引用][C] 地高辛给药方案与血药浓度及临床疗效的关系

李景苏, 蔡长春, 侯艳宁 - 临床误诊误治, 2006

[引用][C] 钠钾泵抑制剂通过调节细胞周期相关蛋白的生成介导肝癌HepG2 细胞周期S 期阻滞与凋亡

高默杰, 徐忠伟, 王凤梅, 陈小义, 呼文亮, 徐瑞成 - 中国药理学通报, 2010

Cardiovascular pharmacogenetics

R Myburgh, WE Hochfeld, TM Dodgen, J Ker… - Pharmacology & …, 2012 - Elsevier
Human genetic variation in the form of single nucleotide polymorphisms as well as more
complex structural variations such as insertions, deletions and copy number variants, is …

[PDF][PDF] Pharmacologically relevant drug interactions of glucagon-like peptide-1 receptor agonists

NMP Maideen - J Anal Pharm Res, 2019 - researchgate.net
Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin mimetics and they are useful
in the treatment of type 2 diabetes mellitus (Type 2 DM). The drugs such as Exenatide …