The human immune system has developed an elaborate network of cascades for dealing
with microbial intruders. Owing to its ability to rapidly recognize and eliminate …

The innate immune system of the human body has developed numerous mechanisms to
control endogenous and exogenous bacteria and thus prevent infections by these …

Complement is an innate immune system that is a first line of defense against pathogens
and facilitates elimination of apoptotic and injured cells. During complement activation, the …

Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that
causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to …

Activation of the complement system and resulting opsonisation with C3b are key events of
the innate immune defense against infections. However, a wide variety of bacterial …

The human complement system is elemental to recognize bacteria, opsonize them for
handling by phagocytes, or kill them by direct lysis. However, successful bacterial pathogens …

The human complement system plays an important role in the defense against invading
pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly …

The plasma proteins of the complement system are essential in the innate immune response
against bacteria. Complement labels bacteria with opsonins to support phagocytosis and …

Bloodstream infection is a major public health concern associated with high mortality and
high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention …

The human host has evolved elaborate protection mechanisms to prevent infection from the
billions of microorganisms to which it host is exposed and is home. One of these systems …