Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …

Background Bronchial thermoplasty is an endoscopic treatment for uncontrolled asthma.
Previous randomised clinical trials have shown that bronchial thermoplasty reduces severe …

Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …

The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse
range of underlying dominant disease processes and pathways despite apparent similarities …

abstract Asthma is characterized by chronic airway inflammation, variable airway narrowing,
and sensory nerve irritation, which manifest as wheezing, dyspnea, chest tightness, and …

Bronchial thermoplasty is an endoscopic therapy for severe asthma. The previously
reported, randomised sham-controlled AIR2 (Asthma Intervention Research 2) trial showed …

For over 150 years, bronchoscopy, especially flexible bronchoscopy, has been a mainstay
for airway inspection, the diagnosis of airway lesions, therapeutic aspiration of airway …

Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma
targeting airway smooth muscle (ASM). Observational studies have shown ASM mass …

Severe asthma is “asthma which requires treatment with high dose inhaled corticosteroids
(ICS) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming …