The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially
among the aging population. The “response-to-injury” model proposed by Dr. Russell Ross …

Introduction: Abnormal status of gene expression plays an important role in tumorigenesis,
progression and metastasis of breast cancer. Mechanisms of gene silence or activation were …

Overexpression of Flap endonuclease 1 (FEN1) has been previously implicated in
hepatocellular carcinoma (HCC), while its expression features and mechanisms remain …

Background A significant desmoplastic response, particularly in the fibroblasts, is a
characteristic of pancreatic ductal adenocarcinoma (PDAC). Increasing evidence has shown …

Overexpression of the flap endonuclease FEN1 has been observed in a variety of cancer
types and is a marker for poor prognosis. To better understand the cellular consequences of …

Neuroblastoma, a paediatric malignant tumor, is initially sensitive to etoposide, a drug to
which many patients develop chemoresistance. In order to investigate the molecular …

Background Hepatocellular carcinoma (HCC), the second leading cause of cancer death
worldwide, alone accounts for over half (466,100) of new cancer cases and 422,100 deaths …

Objective This study aims to identify the potential value of flap endonuclease 1 (FEN1) as a
diagnostic and prognostic marker for breast cancer (BC). Methods ELISA was used to …

Purpose Metastasis of hepatocellular carcinoma (HCC) critically impacts the survival
prognosis of patients, with the pivotal role of hepatocellular carcinoma stem cells in initiating …