Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

N Petryk, S Bultmann, T Bartke… - Nucleic acids …, 2021 - academic.oup.com
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

[HTML][HTML] Diverse mechanisms of centromere specification

BG Mellone, D Fachinetti - Current Biology, 2021 - cell.com
The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

Variation and evolution of human centromeres: a field guide and perspective

KH Miga, IA Alexandrov - Annual review of genetics, 2021 - annualreviews.org
We are entering a new era in genomics where entire centromeric regions are accurately
represented in human reference assemblies. Access to these high-resolution maps will …

[HTML][HTML] CENP-B-mediated DNA loops regulate activity and stability of human centromeres

F Chardon, A Japaridze, H Witt, L Velikovsky… - Molecular cell, 2022 - cell.com
Chromosome inheritance depends on centromeres, epigenetically specified regions of
chromosomes. While conventional human centromeres are known to be built of long tandem …

A complete gap-free diploid genome in Saccharum complex and the genomic footprints of evolution in the highly polyploid Saccharum genus

T Wang, B Wang, X Hua, H Tang, Z Zhang, R Gao, Y Qi… - Nature plants, 2023 - nature.com
A diploid genome in the Saccharum complex facilitates our understanding of evolution in the
highly polyploid Saccharum genus. Here we have generated a complete, gap-free genome …

Human chromosome‐specific aneuploidy is influenced by DNA‐dependent centromeric features

M Dumont, R Gamba, P Gestraud, S Klaasen… - The EMBO …, 2020 - embopress.org
Intrinsic genomic features of individual chromosomes can contribute to chromosome‐
specific aneuploidy. Centromeres are key elements for the maintenance of chromosome …

The genome-wide mutational consequences of DNA hypomethylation

N Besselink, J Keijer, C Vermeulen, S Boymans… - Scientific Reports, 2023 - nature.com
DNA methylation is important for establishing and maintaining cell identity and for genomic
stability. This is achieved by regulating the accessibility of regulatory and transcriptional …

[HTML][HTML] Protective role of curcumin on broiler liver by modulating aflatoxin B1-induced DNA methylation and CYPs expression

R Liu, Y Ding, W Li, S Li, X Li, D Zhao, Y Zhang… - Ecotoxicology and …, 2023 - Elsevier
The purpose of this study was to investigate the role of epigenetic DNA methylation and
CYPs expression in AFB1-exposed broiler liver and the protective effect of curcumin. Sixty …

A near‐complete assembly of asparagus bean provides insights into anthocyanin accumulation in pods

Y Yang, Z Wu, Z Wu, T Li, Z Shen… - Plant Biotechnology …, 2023 - Wiley Online Library
Asparagus bean (Vigna unguiculata ssp. sesquipedialis), a subspecies of V. unguiculata, is
a vital legume crop widely cultivated in Asia for its tender pods consumed as vegetables …

From evolution to function: Two sides of the same CENP-B coin?

R Gamba, D Fachinetti - Experimental Cell Research, 2020 - Elsevier
The centromere is the nucleoproteic chromosomal structure necessary for accurate
chromosome segregation during cell division. One of the earliest centromeric proteins to be …