Recent advances in tumor biology demand detailed analysis of the complex interaction of
tumor cells with their adjacent microenvironment (tumor stroma) to understand the various …

Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …

Mutations causing aberrant splicing are frequently implicated in human diseases including
cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to …

In this investigation, a novel series of quinoline analogues bearing thiazolidinones were
designed and synthesized based on our previous study. Among them, the most potent …

Oncogenic kinases contribute to immunosuppression and modulate the tumor
microenvironment in solid tumors. Increasing evidence supports the fundamental role of …

The advent of immune checkpoint blockade as a new strategy for immunotherapy has
changed the outlook for many aggressive cancers. Although complete tumor eradication is …

In this study, a novel series of 4, 6, 7-trisubstituted quinoline analogues bearing
thiazolidinones were designed and synthesized based on our previous study. Among them …

Metastasis is the biggest challenge in treating breast cancer, and it kills> 40,000 breast
cancer patients annually in the US. Aberrant expression of the RON receptor tyrosine kinase …

c-Raf is a central component of the extracellular signal-regulated kinase (ERK) pathway
which is implicated in the development of many cancer types. RanBPM (Ran-Binding …

Herein, we report the identification, structural optimization, and biological efficacy of thieno
[2, 3-b] pyridines as potent inhibitors of splice variants of the tyrosine kinase recepteur …