[HTML][HTML] The Impact of Lateral Gene Transfer in Chlamydia

H Marti, RJ Suchland, DD Rockey - Frontiers in cellular and infection …, 2022 - frontiersin.org
Lateral gene transfer (LGT) facilitates many processes in bacterial ecology and
pathogenesis, especially regarding pathogen evolution and the spread of antibiotic …

[HTML][HTML] Advances in genetic manipulation of Chlamydia trachomatis

W Wan, D Li, D Li, J Jiao - Frontiers in Immunology, 2023 - frontiersin.org
Chlamydia trachomatis, one species of Chlamydia spp., has the greatest impact on human
health and is the main cause of bacterial sexually transmitted diseases and preventable …

Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis

S Pan, AA Jensen, NA Wood, B Henrichfreise… - Mbio, 2023 - Am Soc Microbiol
Bacterial AAA+ unfoldases are crucial for bacterial physiology by recognizing specific
substrates and, typically, unfolding them for degradation by a proteolytic component. The c …

[HTML][HTML] Chlamydia trachomatis TmeB antagonizes actin polymerization via direct interference with Arp2/3 activity

KR Scanlon, G Keb, K Wolf, TJ Jewett… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Chlamydia trachomatis is an obligate intracellular pathogen that actively promotes invasion
of epithelial cells. A virulence-associated type III secretion system contributes to chlamydial …

Chlamydia trachomatis TmeA directly activates N-WASP to promote actin polymerization and functions synergistically with TarP during invasion

G Keb, J Ferrell, KR Scanlon, TJ Jewett, KA Fields - MBio, 2021 - Am Soc Microbiol
Chlamydia trachomatis is a medically significant human pathogen and is an epithelial-tropic
obligate intracellular parasite. Invasion of nonprofessional phagocytes represents a crucial …

Tag-dependent substrate selection of ClpX underlies secondary differentiation of Chlamydia trachomatis

NA Wood, AR Swoboda, AM Blocker, DJ Fisher… - Mbio, 2022 - Am Soc Microbiol
Despite having a highly reduced genome, Chlamydia trachomatis undergoes a complex
developmental cycle in which the bacteria differentiate between the following two …

Fluorescence-reported allelic exchange mutagenesis reveals a role for Chlamydia trachomatis TmeA in invasion that is independent of host AHNAK

MJ McKuen, KE Mueller, YS Bae… - Infection and …, 2017 - Am Soc Microbiol
Development of approaches to genetically manipulate Chlamydia is fostering important
advances in understanding pathogenesis. F luorescence-r eported a llelic e xchange m …

Fluorescence-Reported Allelic Exchange Mutagenesis-Mediated Gene Deletion Indicates a Requirement for Chlamydia trachomatis Tarp during In Vivo Infectivity …

S Ghosh, EA Ruelke, JC Ferrell, MD Bodero… - Infection and …, 2020 - Am Soc Microbiol
The translocated actin recruiting phosphoprotein (Tarp) is a multidomain type III secreted
effector used by Chlamydia trachomatis. In aggregate, existing data suggest a role of this …

The ClpX and ClpP2 orthologs of Chlamydia trachomatis perform discrete and essential functions in organism growth and development

NA Wood, AM Blocker, MA Seleem, M Conda-Sheridan… - MBio, 2020 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium that undergoes a complex
developmental cycle in which the bacterium differentiates between two functionally and …

Floxed-cassette allelic exchange mutagenesis enables markerless gene deletion in Chlamydia trachomatis and can reverse cassette-induced polar effects

G Keb, R Hayman, KA Fields - Journal of Bacteriology, 2018 - Am Soc Microbiol
As obligate intracellular bacteria, Chlamydia spp. have evolved numerous, likely intricate,
mechanisms to create and maintain a privileged intracellular niche. Recent progress in …