Approximately, 10–15% of women of reproductive age are affected by endometriosis, which
often leads to infertility. Endometriosis often has an inherited component, and several …

Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles
associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep …

Background In recent years, cancer rates have been rising among reproductive-age women.
Thus, chemotherapy exposure has become an important cause of premature ovarian failure …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Background Millions of children have been born throughout the world thanks to ARTs, the
harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the …

Nrf2 is a redox sensitive transcription factor regulating the expression of antioxidant genes
as defense mechanism against various stressors. The aim of this study is to investigate the …

Observational human data and several lines of animal experimental data indicate that
maternal obesity impairs offspring health. Here, we comprehensively tested the model that …

Doxorubicin (DOX) is a widely used chemotherapeutic agent with demonstrated
reproductive toxicity. This study sought to determine the DOX-induced toxicity in the ovary …

This study sought to modulate factors that reduce embryo quality in in vitro culture (IVC)
systems. Over eight replicates, 3075 oocytes were cultured in in vitro maturation media …

В статье проанализированы данные систематических обзоров и рандомизированных
клинических исследований, посвященных современным представлениям о патогенезе …