Cognitive decline is believed to be associated with neurodegenerative processes involving
excitotoxicity, oxidative damage, inflammation, and microvascular and blood-brain barrier …

Chronic pain is a persistent, complex condition that contributes to impaired mood, anxiety
and emotional problems. Osteoarthritis (OA) is one of the major causes of chronic pain in …

Abstract The 2-pentadecyl-2-oxazoline (PEA-OXA) is a natural compound with protective
action in neuro-inflammation. We have previously shown that PEA-OXA behaves as an α2 …

Depression is among the most frequent psychiatric comorbid conditions in Alzheimer
disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big …

Transient global amnesia, both persistent and transient, is a very common neuropsychiatric
syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test …

Abstract Aim 2-Pentadecyl-2-oxazoline (PEA-OXA), the oxazoline derivative of N-
palmitoylethanolamine, exerts anti-inflammatory activity; however, very little is known about …

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several
antineoplastics, such as oxaliplatin (L-OHP). The aim of the present work was to evaluate …

Chronic social isolation generates a persistent state of stress associated with obesity along
with some neuro-endocrine disorders and central behavioral sequelae (eg anxiety …

Vestibulodynia is a complex pain disorder characterized by chronic discomfort in the vulvar
region, often accompanied by tactile allodynia and spontaneous pain. In patients a …

We investigated the effects of histamine and GABA A receptor agents on pain and
depression-like behaviors and their interaction using a tail-flick test and the forced swimming …