Development of Personalized Strategies for Precisely Battling Malignant Melanoma
AJ Isaak, GGR Clements, RGM Buenaventura… - International Journal of …, 2024 - mdpi.com
Simple Summary Precision oncology is emerging as a viable option to improve survival in
patients who fail to remain disease-free even after the employment of currently available …
patients who fail to remain disease-free even after the employment of currently available …
Pharmacophore‐linked pyrazolo[3,4‐d]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies
Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …
Druggable targets of protein tyrosine phosphatase Family, viz. PTP1B, SHP2, Cdc25, and LMW-PTP: Current scenario on medicinal Attributes, and SAR insights
R Kohal, P Kumari, GD Gupta, SK Verma - Bioorganic Chemistry, 2024 - Elsevier
Protein tyrosine phosphatases (PTPs) are the class of dephosphorylation enzymes that
catalyze the removal of phosphate groups from tyrosine residues on proteins responsible for …
catalyze the removal of phosphate groups from tyrosine residues on proteins responsible for …
Comparative proteomic analysis of insulin receptor isoform A and B signaling
R Malaguarnera, C Gabriele, G Santamaria… - Molecular and Cellular …, 2022 - Elsevier
The insulin receptor (IR) gene undergoes differential splicing generating two IR isoforms, IR-
A and IR-B. The roles of IR-A in cancer and of IR-B in metabolic regulation are well known …
A and IR-B. The roles of IR-A in cancer and of IR-B in metabolic regulation are well known …
Evidence of insulin-sensitizing and mimetic activity of the sesquiterpene quinone avarone, a protein tyrosine phosphatase 1B and aldose reductase dual targeting …
M Casertano, M Genovese, A Santi, E Pranzini… - Pharmaceutics, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose
homeostasis and serious long-term complications. First-line therapeutic options for T2DM …
homeostasis and serious long-term complications. First-line therapeutic options for T2DM …
Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer
T Wang, X Ba, X Zhang, N Zhang, G Wang… - Frontiers in …, 2022 - frontiersin.org
Protein tyrosine phosphatases function in dephosphorylating target proteins to regulate
signaling pathways that control a broad spectrum of fundamental physiological and …
signaling pathways that control a broad spectrum of fundamental physiological and …
Editorial on Special Issue “Advances and Novel Treatment Options in Metastatic Melanoma”
A Carè, D Del Bufalo, A Facchiano - Cancers, 2022 - mdpi.com
Investigating mechanisms controlling melanoma setup, development and progression is
currently an extremely hot and rapidly evolving topic. Immunotherapy-and target therapy …
currently an extremely hot and rapidly evolving topic. Immunotherapy-and target therapy …
The Low-Molecular Weight Protein Arginine Phosphatase PtpB Affects Nuclease Production, Cell Wall Integrity, and Uptake Rates of Staphylococcus aureus by …
MI Elhawy, V Molle, SL Becker, M Bischoff - International Journal of …, 2021 - mdpi.com
The epidemiological success of Staphylococcus aureus as a versatile pathogen in mammals
is largely attributed to its virulence factor repertoire and the sophisticated regulatory network …
is largely attributed to its virulence factor repertoire and the sophisticated regulatory network …
Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti-cancer Drug Target
A Kambaru, N Chaudhary - Current Pharmaceutical …, 2022 - ingentaconnect.com
Protein Tyrosine Phosphatase (PTP) superfamily is a key enzyme involved in the regulation
of growth-related cell signaling cascades, such as the RAS/MAPK pathway, that directly …
of growth-related cell signaling cascades, such as the RAS/MAPK pathway, that directly …
A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth
Post‐translational modifications, especially reversible phosphorylation, are among the most
common mechanisms that regulate protein function and biological processes in Plasmodium …
common mechanisms that regulate protein function and biological processes in Plasmodium …