PI3K/AKT/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects
Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …
death through malignancies among women in developed countries. Population …
Cell biology of canonical Wnt signaling
LV Albrecht, N Tejeda-Muñoz… - Annual review of cell …, 2021 - annualreviews.org
Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …
stabilization. We review recent investigations that uncover new cell physiological effects …
The cellular and physiological basis for lung repair and regeneration: past, present, and future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics
Elucidating enzyme–substrate relationships in posttranslational modification (PTM) networks
is crucial for understanding signal transduction pathways but is technically difficult because …
is crucial for understanding signal transduction pathways but is technically difficult because …
Molecular mechanism of fast endophilin-mediated endocytosis
A Casamento, E Boucrot - Biochemical Journal, 2020 - portlandpress.com
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-
mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional …
mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional …
ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein
Abnormal tau protein impairs mitochondrial function, including transport, dynamics, and
bioenergetics. Mitochondria interact with the endoplasmic reticulum (ER) via mitochondria …
bioenergetics. Mitochondria interact with the endoplasmic reticulum (ER) via mitochondria …
Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 …
A Belal, NM Abdel Gawad, ABM Mehany… - Journal of enzyme …, 2022 - Taylor & Francis
A new series of 1 H-pyrrole (6a–c, 8a–c), pyrrolo [3, 2-d] pyrimidines (9a–c) and pyrrolo [3, 2-
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
Development of the cochlea
EC Driver, MW Kelley - Development, 2020 - journals.biologists.com
The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …
primary structure for the perception of sound. Along the length of the cochlear spiral is the …
Kinases as potential therapeutic targets for anti-coronaviral therapy
T Pillaiyar, S Laufer - Journal of Medicinal Chemistry, 2021 - ACS Publications
The global coronavirus disease-19 (COVID-19) has affected more than 140 million and
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …
[HTML][HTML] Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine …
Introduction Alzheimer's disease (AD) is a progressive brain disorder, and one of the most
common causes of dementia and amnesia. Due to the complex pathogenesis of AD, the …
common causes of dementia and amnesia. Due to the complex pathogenesis of AD, the …