The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …

Conspectus SARS-CoV-2 is the etiological pathogen of the COVID-19 pandemic, which led
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The devastating COVID-19 pandemic has caused more than six million deaths worldwide
during the last 2 years. Effective therapeutic agents are greatly needed, yet promising magic …

Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

Abstract SARS-CoV-2 3CL protease is one of the key targets for drug development against
COVID-19. Most known SARS-CoV-2 3CL protease inhibitors act by covalently binding to …

Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), remains a global public health crisis. The reduced efficacy of therapeutic …

In this study, an integrated in silico–in vitro approach was employed to discover natural
products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, ie, main …