Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction
E Wigenstam, E Artursson, A Bucht, L Thors - Chemico-Biological …, 2022 - Elsevier
Exposure to highly toxic organophosphorus compounds causes inhibition of the enzyme
acetylcholinesterase resulting in a cholinergic toxidrome and innervation of receptors in the …
acetylcholinesterase resulting in a cholinergic toxidrome and innervation of receptors in the …
Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges
D Zhao, P Huang, L Yu, Y He - Clinical Pharmacokinetics, 2024 - Springer
Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug
interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating …
interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating …
The estimation and translation uncertainties in applying NOAEL to clinical dose escalation
C Chen, SM Lavezzi… - Clinical and Translational …, 2024 - Wiley Online Library
The systemic exposure at the no‐observed‐adverse‐effect‐level (NOAEL) estimated from
animals is an important criterion commonly applied to guard the safety of participants in …
animals is an important criterion commonly applied to guard the safety of participants in …
Targeting mitochondrial metabolism as a promising therapeutic strategy in cancer
ML Stoker - 2024 - ora.ox.ac.uk
Since the discovery of the Warburg effect in the 1920s, our understanding of cancer
metabolism has evolved. Increasing evidence shows cancer cells are metabolically plastic …
metabolism has evolved. Increasing evidence shows cancer cells are metabolically plastic …