Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

Protein condensates are complex fluids that can change their material properties with time.
However, an appropriate rheological description of these fluids remains missing. We …

Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

Many proteins perform their functions within membraneless organelles, where they form a
liquid-like condensed state, also known as droplet state. The FuzDrop method predicts the …

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

The metabolic adaptation of eukaryotic cells to hypoxia involves increasing dependence
upon glycolytic adenosine triphosphate (ATP) production, an event with consequences for …

Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …

Energy metabolism supports neuronal function. While it is well established that changes in
energy metabolism underpin brain plasticity and function, less is known about how …

Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …