Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological
conditions and are increased by stress and infections, and in autoinflammatory and …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …

Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

Improving efficacy of immune checkpoint blockade for cancer can be facilitated by
combining these agents with each other and/or with other conventional or targeted …

Type I interferons, which make up the first cytokine family to be described and are the
essential mediators of antivirus host defense, have emerged as central elements in the …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the
respiratory tract but also causes neurological symptoms such as loss of smell and taste …

Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected
activities in inflammation and infection; whether viral infections upregulate biologically …

Type I interferon is promising in treating different kinds of tumors, but has been limited by its
toxicity, lack of tumor targeting, and very short half-life. To target tumors, reduce systemic …