Conspectus “Drug resistance is an unavoidable consequence of the use of drugs; however,
the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor …

Over the last century, endophytic fungi have gained tremendous attention due to their ability
to produce novel bioactive compounds exhibiting varied biological properties and are …

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium
tuberculosis is required to accelerate the development of rapid drug susceptibility testing …

To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …

Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …

Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …

The emergence of drug-resistant tuberculosis is a major global public health concern that
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …

Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …

Advances in genomics and computing are transforming the capacity for the characterization
of biological systems, and researchers are now poised for a precision-focused …

Rapid and accurate drug susceptibility testing (DST) is essential for the treatment of multi-
and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of …