Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration

I Austin-Zimmerman, DF Levey… - Nature …, 2023 - nature.com
Sleep duration has been linked to a wide range of negative health outcomes and to reduced
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …

Establishing causal relationships between sleep and adiposity traits using Mendelian randomization

BL Hayes, M Vabistsevits, RM Martin, DA Lawlor… - …, 2023 - Wiley Online Library
Objective The aim of this study was to systematically evaluate the direction of any potential
causal effect between sleep and adiposity traits. Methods Two‐sample Mendelian …

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

R Noordam, MM Bos, H Wang, TW Winkler… - Nature …, 2019 - nature.com
Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …

[HTML][HTML] Evidence for causal effects of sleep disturbances on risk for osteoarthritis: a univariable and multivariable Mendelian randomization study

J Ni, W Zhou, H Cen, G Chen, J Huang, K Yin… - Osteoarthritis and …, 2022 - Elsevier
Objective To disentangle whether sleep disturbances have a causal effect on the risk of
osteoarthritis (OA) using genetically based approaches. Method We performed univariable …

Sleep duration and risk of overall and 22 site‐specific cancers: A Mendelian randomization study

OE Titova, K Michaëlsson, M Vithayathil… - … journal of cancer, 2021 - Wiley Online Library
Studies of sleep duration in relation to the risk of site‐specific cancers other than breast
cancer are scarce. Furthermore, the available results are inconclusive and the causality …

Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms

F Doldur-Balli, T Imamura, OJ Veatch, NN Gong… - Sleep medicine …, 2022 - Elsevier
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …

Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis

EL Harshfield, MK Georgakis, R Malik, M Dichgans… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Assessing whether modifiable risk factors are causally associated
with stroke risk is important in planning public health measures, but determining causality …

Physical behaviors and chronotype in people with type 2 diabetes

J Henson, AV Rowlands, E Baldry, EM Brady… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction Previous investigations have suggested that evening chronotypes may be more
susceptible to obesity-related metabolic alterations. However, whether device-measured …

[HTML][HTML] Genetic evidence for the causal effects of C–reactive protein on self-reported habitual sleep duration

O Iakunchykova, M Pan, IK Amlien, JM Roe… - Brain, behavior, & …, 2024 - Elsevier
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship
between chronic inflammation and habitual sleep duration is elusive. Here, we study this …

[HTML][HTML] Genome-wide association study of breakfast skipping links clock regulation with food timing

HS Dashti, J Merino, JM Lane, Y Song, CE Smith… - The American journal of …, 2019 - Elsevier
Background Little is known about the contribution of genetic variation to food timing, and
breakfast has been determined to exhibit the most heritable meal timing. As breakfast timing …