Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration
I Austin-Zimmerman, DF Levey… - Nature …, 2023 - nature.com
Sleep duration has been linked to a wide range of negative health outcomes and to reduced
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …
Establishing causal relationships between sleep and adiposity traits using Mendelian randomization
Objective The aim of this study was to systematically evaluate the direction of any potential
causal effect between sleep and adiposity traits. Methods Two‐sample Mendelian …
causal effect between sleep and adiposity traits. Methods Two‐sample Mendelian …
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
R Noordam, MM Bos, H Wang, TW Winkler… - Nature …, 2019 - nature.com
Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …
[HTML][HTML] Evidence for causal effects of sleep disturbances on risk for osteoarthritis: a univariable and multivariable Mendelian randomization study
J Ni, W Zhou, H Cen, G Chen, J Huang, K Yin… - Osteoarthritis and …, 2022 - Elsevier
Objective To disentangle whether sleep disturbances have a causal effect on the risk of
osteoarthritis (OA) using genetically based approaches. Method We performed univariable …
osteoarthritis (OA) using genetically based approaches. Method We performed univariable …
Sleep duration and risk of overall and 22 site‐specific cancers: A Mendelian randomization study
OE Titova, K Michaëlsson, M Vithayathil… - … journal of cancer, 2021 - Wiley Online Library
Studies of sleep duration in relation to the risk of site‐specific cancers other than breast
cancer are scarce. Furthermore, the available results are inconclusive and the causality …
cancer are scarce. Furthermore, the available results are inconclusive and the causality …
Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …
a transdiagnostic process that can account for behavioral deficits and influence underlying …
Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis
Background and Purpose: Assessing whether modifiable risk factors are causally associated
with stroke risk is important in planning public health measures, but determining causality …
with stroke risk is important in planning public health measures, but determining causality …
Physical behaviors and chronotype in people with type 2 diabetes
Introduction Previous investigations have suggested that evening chronotypes may be more
susceptible to obesity-related metabolic alterations. However, whether device-measured …
susceptible to obesity-related metabolic alterations. However, whether device-measured …
[HTML][HTML] Genetic evidence for the causal effects of C–reactive protein on self-reported habitual sleep duration
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship
between chronic inflammation and habitual sleep duration is elusive. Here, we study this …
between chronic inflammation and habitual sleep duration is elusive. Here, we study this …
[HTML][HTML] Genome-wide association study of breakfast skipping links clock regulation with food timing
Background Little is known about the contribution of genetic variation to food timing, and
breakfast has been determined to exhibit the most heritable meal timing. As breakfast timing …
breakfast has been determined to exhibit the most heritable meal timing. As breakfast timing …