Matrix metalloproteinases (MMPs) appear to be ideal drug targets—they are disease-
associated, extracellular enzymes with a dependence on zinc for activity. This apparently …

The role of inflammation in the development of aortic aneurysms is emerging, along with the
potential diagnostic and therapeutical potential of this correlation. Abdominal aorta …

In the last decade, the identification of enzymes that regulate acetylation of histones and
nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in …

At least 56 matrix metalloproteinase (MMP) inhibitors have been pursued as clinical
candidates since the late 1970's when the first drug discovery program targeting this enzyme …

Type I fibrillar collagen is the most abundant protein in the human body, crucial for the
formation and strength of bones, skin, and tendon. Proteolytic enzymes are essential for …

Abdominal aortic aneurysm (AAA) is histologically characterized by medial degeneration
and various degrees of chronic adventitial inflammation, although the mechanisms for …

Background Abdominal aortic aneurysm (AAA) is a leading cause of mortality and morbidity
in the elderly. Currently, there remain no effective drugs that can prevent the growth of …

Abdominal aortic aneurysm (AAA) rupture is believed to represent the culmination of a
complex mechanism partially driven by the forces exerted along the lumen. In the present …

Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events
and microvascular complications. These complications contribute to the morbidity and …

Rationale: Matrix metalloproteinases (MMPs)–mediated extracellular matrix destruction is
the major cause of development and progression of abdominal aortic aneurysms. Systemic …