Matrix metalloproteinases (MMPs, matrixins) are a family of secreted and membrane-bound
zinc-dependent endopeptidases that have the combined capacity to degrade all the …

BACKGROUND: Varicose veins are a common disorder of extensive venous dilation and
remodeling with an as-yet unclear mechanism. Studies have shown increased plasma and …

Objective—Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in
various chronic inflammatory diseases. In the present study, we asked whether Angptl2 and …

Abdominal aortic aneurysm (AAA) is defined as a permanent dilatation of the abdominal
aorta that exceeds 3 cm. Most AAAs arise in the portion of abdominal aorta distal to the renal …

Oxidative stress leads to vascular damage and participates in the pathomechanisms of
aortic dissection and aneurysm formation. Here we study aortic dissection in mice deficient …

Objective: Currently, there are no approved drugs for abdominal aortic aneurysm (AAA)
treatment, likely due to limited understanding of the primary molecular mechanisms …

Undoubtedly the applications of polymers are rapidly evolving. Technology is continually
changing and quickly advancing as polymers are needed to solve a variety of day-to-day …

Matrix metalloproteinases (MMPs) are extracellular matrix–modifying enzymes that are
important in many physiologic and pathologic vascular processes. Dysregulation of MMP …

Aims Increased angiogenesis, chronic inflammation, and extracellular matrix degradation
are the major pathological features of abdominal aortic aneurysm (AAA). We sought to …

Matrix metalloproteinases (MMPs) are zinc-and calcium-dependent endoproteinases that
have the ability to break down extracellular matrix. The large range of MMPs' functions …