TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood …

BR Mattos, GF Bonacio, TR Vitorino, VT Garcia… - Biochemical …, 2020 - Elsevier
Systemic arterial hypertension is a public health problem associated with an increased risk
of cardiovascular disease. Matrix metalloproteinases (MMP) are endopeptidases that …

[HTML][HTML] Synthesis, hemorheological and antifibrotic activity of newly synthesized 3-acetyl-2, 4, 6-trimethylpyridine derivatives

Z Shulgau, A Stalinskaya, S Sergazy… - Arabian Journal of …, 2023 - Elsevier
Pyridine derivatives still attract the attention of many researchers for their comprehensive
biological research, possible promotion to the pharmaceutical market in order to be used as …

[HTML][HTML] Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives

S Sergazy, Z Shulgau, A Zhulikeyeva, Y Ramankulov… - Molecules, 2022 - mdpi.com
Currently, studies are being conducted on the possible role of the cytoprotective effect of
biologically active substances in conditions of cerebral hypoxia or cardiomyopathies. At the …

Effects of adding pentoxifylline to captopril on primary hypertension: A pilot randomized clinical trial

H Namdar, E Khani, MH Pourrashid… - The Journal of …, 2020 - Wiley Online Library
Because of the key role blood viscosity plays in the regulation of blood pressure (BP) and
the hemorheological effects of pentoxifylline (PTX), this study was conducted to evaluate …

Consumo de etanol induz fenótipo pró-contrátil em tecido adiposo perivascular de artérias de resistência: participação dos receptores mineralocorticoides

IVO Martins - 2023 - teses.usp.br
O consumo crônico de etanol é um fator de risco para o desenvolvimento de doenças
cardiovasculares como a hipertensão arterial. O mecanismo pelo qual o etanol induz …

Use of Pentoxifylline combined with captopril/losartan in hypertensive or diabetic patients: An integrative review of randomized clinical trials

YS Nascimento, YS Nascimento… - Research, Society and …, 2023 - rsdjournal.org
Objective: To perform an integrative literature review to analyze the effects of the use of
Pentoxifylline (PTX) combined and/or compared to captopril or losartan. Methodology: An …

Cytoprotective Activity of Newly Synthesized 3-(arylmethyl)-6-methyl-4-phenylpyridin-2 (1H)-ones derivatives

S Sergazy, Z Shulgau, A Zhulikeyeva, Y Ramankulov… - 2022 - preprints.org
Currently, studies are being conducted on the possible role of the cytoprotective effect of
biologically active substances in conditions of cerebral hypoxia or cardiomyopathies. At the …

The randomized clinical trial of pentoxifylline for reduction of blood pressure in patients with primary hypertension

H Namdar, S Khiali… - Pharmaceutical …, 2020 - archives.articleproms.com
Background: Pentoxifylline (PTX) is a xanthine derivative with the potential cardiovascular
effects. This study was done to evaluate the impact of pentoxifylline on blood pressure when …

[PDF][PDF] The uses of pentoxifylline in cardiology and hypertension

AJ Al-Mosawi - Clinical Research and Clinical Case Reports, 2021 - aditum.org
Pentoxifylline is a xanthine derivative with vasodilatory properties and rheological properties
on blood that made it useful in the treatment of intermittent claudication. Pentoxifylline also …

A Case of Scleredema Diabeticorum: Could Pentoxifylline Be a Therapeutic Option?

H Aktaş, S Öner, Z Öner - The Ulutas Medical Journal, 2019 - dergipark.org.tr
Background: Scleredema diabeticorum is a dermatosis characterized by hardening of skin
over the upper back. It is commonly seen in poor-controlled diabetic patients. Therapeutic …