Bevacizumab (BV) is a humanized monoclonal antibody targeting vascular endothelial
growth factor and it is the first molecular-targeted agent to be used for the treatment of …

Molecular imaging continues to influence every aspect of cancer care including detection,
diagnosis, staging and therapy response assessment. Recent advances in the …

Background Despite standard treatment for epithelial ovarian cancer (EOC), that involves
cytoreductive surgery followed by platinum-based chemotherapy, and initial high response …

Standard treatment of cervical cancer (CC) consists of surgery in the early stages and of
chemoradiation in locally advanced disease. Metastatic CC has a poor prognosis and is …

Introduction: Endometrial carcinoma represents the most frequent gynecologic tumor in
developed countries. The majority of women presents with low-grade tumors but a …

Currently we are more and more improving our knowledge about the characteristics and the
role of cancer stem cells in human cancer. Particularly we have realized that self-renewing …

The prolongation of progression-free survival (PFS) in patients with advanced ovarian
cancer by antiangiogenic therapy has been shown in several clinical trials. However …

Pathological angiogenesis in the retina is a leading cause of serious vision loss in
potentially blinding eye diseases, including proliferative diabetic retinopathy, retinopathy of …

When to start and end antiangiogenesis therapy and the choice of optimal treatment
combinations remain controversial. Further evaluation of personalized novel angiogenesis …

This chapter deconstructs the process of angiogenesis into its component parts in order to
provide simple assays to measure discrete endothelial cell functions. The techniques …