Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Definitions and classification of malformations of cortical development: practical guidelines
M Severino, AF Geraldo, N Utz, D Tortora, I Pogledic… - Brain, 2020 - academic.oup.com
Malformations of cortical development are a group of rare disorders commonly manifesting
with developmental delay, cerebral palsy or seizures. The neurological outcome is …
with developmental delay, cerebral palsy or seizures. The neurological outcome is …
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …
disorders characterized by early-onset, often severe epileptic seizures and EEG …
[PDF][PDF] Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells
TJ Nowakowski, AA Pollen, E Di Lullo… - Cell stem cell, 2016 - cell.com
The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in
fetal abnormalities and microcephaly. However, information about the underlying molecular …
fetal abnormalities and microcephaly. However, information about the underlying molecular …
Эпилепсия у детей и взрослых женщин и мужчин
ВА Карлов - 2019 - elibrary.ru
В руководстве представлены результаты 60-летней работы автора в области детской
и взрослой неврологии и эпилептологии. Впервые эпилептология представлена в …
и взрослой неврологии и эпилептологии. Впервые эпилептология представлена в …
The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission 1
I Blümcke, M Thom, E Aronica, DD Armstrong… - 2011 - Wiley Online Library
Purpose: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex
and are very frequently associated with epilepsy in both children and adults. A broad …
and are very frequently associated with epilepsy in both children and adults. A broad …
[HTML][HTML] Physical biology of human brain development
Neurodevelopment is a complex, dynamic process that involves a precisely orchestrated
sequence of genetic, environmental, biochemical, and physical events. Developmental …
sequence of genetic, environmental, biochemical, and physical events. Developmental …
Deconstructing cortical folding: genetic, cellular and mechanical determinants
C Llinares-Benadero, V Borrell - Nature Reviews Neuroscience, 2019 - nature.com
Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …
is associated with dramatic increases in size and complexity. New animal models, genetic …
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
JH Lee, M Huynh, JL Silhavy, S Kim, T Dixon-Salazar… - Nature …, 2012 - nature.com
De novo somatic mutations in focal areas are well documented in diseases such as
neoplasia but are rarely reported in malformation of the developing brain …
neoplasia but are rarely reported in malformation of the developing brain …
[HTML][HTML] Genes that affect brain structure and function identified by rare variant analyses of Mendelian neurologic disease
E Karaca, T Harel, D Pehlivan, SN Jhangiani… - Neuron, 2015 - cell.com
Development of the human nervous system involves complex interactions among
fundamental cellular processes and requires a multitude of genes, many of which remain to …
fundamental cellular processes and requires a multitude of genes, many of which remain to …